Charles Cecil Wyche was born in Prosperity, the son of Dr. Cyril Thomas and Carrie Sease Wyche. He received a B.S. degree from The Citadel, attended the University of South Carolina and Georgetown University, where he received an LL.D. degree in 1909. He was also admitted to the Bar that same year.
He practiced in Spartanburg with Governor John Gary Evans and later with Miller Foster. He was a Representative from Spartanburg County from 1912 to 1914.
During World War I, he volunteered and rose to First Lieutenant Major, AEJ. Upon returning to his practice, he served as City Attorney, County Attorney, Special Circuit Judge, and Special Associate Justice. He was a member of the leading law firm of Congressman Nichols, Senator Byrnes, and Circuit Judge Russell.
He was a member of the South Carolina and American Bar Associations; the American Law Institute and the American Judicature Society. In 1933, he was appointed U.S. Attorney and in 1937, became a U.S. District Judge. Judge Wyche served with distinction for twenty-nine years, becoming Senior District Judge in America.
His courage, compassion, thirst for justice, intuitive ability, mastery of evidence, knowledge of the law and human nature made him a great jurist. He despised hypocrisy.
Judge Wyche was married to Evelyn Crawford and they had one child, Evelyn Wyche Camp.