Edgeworth Blythe was the son of Absalom and Emily Earle Blythe. He attended Furman University and graduated from the Citadel in 1891 with a B.S. He taught both in the public schools and at Clemson College from 1894 to 1896.
In 1896, he was admitted to the Bar and joined his father’s law practice. In 1900, he entered the University of Michigan Law School and earned its LL.B. in 1901. He served as a United States Commissioner from 1903 until 1917, was appointed as a United States Referee in Bankruptcy in 1921, served as a City and County Attorney and was President of the Greenville County Bar.
His distinguished law partners included: Clement and H.J. Haynsworth, L.O. Patterson, James A. McCullough, B.F. Martin, and Proctor Bonham.
He organized Company “A”, 1st Infantry, South Carolina National Guard, in 1899 and rose to the rank of Colonel. He served on the Mexican border in 1916 and was a Major in the United States Army during World War I.
In 1906, he married Miss Anna Hardin and they had three sons. He served as Warden of Christ Episcopal Church, Master of Recovergy Lodge AFM, President of the Rotary Club, twice Chairman of the City School Board, and on the Citadel Board of Visitors.
Friendly, with military bearing, energetic, and thorough, he sought always to occupy his time worthily. A gentleman and able lawyer.